Zytiga

Understanding the Recent Advances in Treating Castrate Sensitive Prostate Cancer 

Understanding the Recent Advances in Treating Castrate Sensitive Prostate Cancer 

Abiraterone, enzalutamide, apalutamide, and docetaxel could be considered for this patient population (castrate sensitive prostate cancer patients), noted Taplin. "None of us can [confirm] that one [option] is better than the other; [the treatment decision] needs to be individualized [by weighing the] pros and cons [with each agent] for each patient," Taplin concluded.

Switching from Abiraterone Plus Prednisone to Abiraterone Plus Dexamethasone Can Extend Its Effectiveness

Switching from Abiraterone Plus Prednisone to Abiraterone Plus Dexamethasone Can Extend Its Effectiveness

A timed steroid switch from prednisone to dexamethasone appears to be a safe and non‐expensive way of obtaining long‐term responses to Zytiga in selected men with metastatic castrate resistant prostate cancer (mCRPC).

Statins, Vitamin D and Zytiga

Statins, Vitamin D and Zytiga

A post hoc analysis of two randomized clinical trials shows some evidence that taking statins and vitamin D supplements might reduce the risk of death in men who have castrate resistant prostate cancer (CRPC) who are also taking the drug Zytiga (abiraterone acetate or AA) with prednisone.

Statins and Vitamin D Might Reduce the Risk of Death in Men with Castrate Resistant Prostate Cancer Taking Zytiga 

Statins and Vitamin D Might Reduce the Risk of Death in Men with Castrate Resistant Prostate Cancer Taking Zytiga 

In this data analysis from two prospective randomized clinical trials, statin and vitamin D use was associated with superior overall survival in men with metastatic CRPC who were treated with Zytiga and prednisone.

When to Start ADT With A PSA Only Recurrence

Deferred hormone therapy (ADT) for in relapsing M0 (negative scans) prostate cancer patients is associated with prolonged overall survival (OS) measured from the time of local treatment, comparable to OS with salvage ADT in the contemporary experience.

Study Shows Denosumab Safe & Effective in Increasing Bone Density in Non-metastatic Prostate Cancer

Prostate cancer treatments, particularly hormone therapy (ADT) can have a significant effect on speeding up the process of thinning and weakening the bones. There are some available treatments (Zoledronic acid aka Zoladex and denosumab aka Xgeva) which are designed to slow down or reverse this process; however, they are known to have many adverse side effects themselves.  These side effects can include severe fractures of the femur which could limit survival and cataracts.  For this reason, these treatments are usually used later, when men become castrate resistant and metastatic.  

Can You Use Low Dose Zytiga with Food?

The standard dose of abiraterone acetate (Zytiga) is 1,000 mg. taken on an empty stomach, however, when just 250 mgs are taken with food, it seems that for many men this lower dosage has the same activity as Zytiga at 1,000 mg without food. 

Lynparza with Zytiga Improves Outcomes

Recently presented data has shown that there is a clinical improvement in median radiologic progression-free survival (rPFS) when olaparib (Lynparza) is used in combination with abiraterone (ZYTIGA) compared to abiraterone alone in men with metastatic castration-resistant prostate cancer (mCRPC). 

Xofigo (Radium-223) - Cautionary Information

The European Medicines Agency (EMA) has recommended that the use of Xofigo (Radium-223) be restricted.  The restrictions, because of safety and efficacy concerns in men with castrate resistant prostate cancer (mCRPC), include that Xofigo can be used only after two other treatments have been taken; when other therapies cannot be used and not in combination with other 2nd line hormone therapies. 

First Line Treatment for Newly Diagnosed Metastatic Prostate Cancer

Initially being diagnosed with metastatic, or advanced prostate cancer is not great.  Metastatic prostate cancer is not curable and will be terminal if you don’t die from another cause.  

We now have a number of what we consider second-line treatments for prostate cancer, drugs like Zytiga, Xtandi and Taxotere (chemotherapy).  

We are beginning to recognize the value of the early use of these second line drugs along with first line ADT for men who are initially diagnosed with metastatic prostate cancer.  

Is Abiraterone Acetate (Zytiga) A Good Alternative for Men with Prostate Cancer Who Are Not Responsive to Androgen Deprivation Therapy (ADT)? 

Men with metastatic prostate cancer (mCRPC) who do not respond to hormone therapy (ADT) or who experience early progression (≤1year) have a poor prognosis.   There is no consensus regarding the proper next therapy for these men.  

Comparing the Efficacy of the Treatment Options of Metastatic, Castration-Resistant, Docetaxel-Resistant Prostate Cancer

There was a large meta-analysis recently published that compared the efficacy of abiraterone acetate (Zytiga), enzalutamide (Xtandi), cabazitaxel (Jevtana) and Radium-223 (Xofigo) in the treatment of castration-resistant, docetaxel-resistant metastatic prostate cancer.

Taking Zytiga At A Lower Dose With Food

Since abiraterone acetate (Zytiga) was approved for men with metastatic prostate cancer, it is well known that taking the drug with food in your stomach as opposed to having an empty stomach enhances the amount of drug that becomes active.  Given the very high cost of Zytiga, many men have been tempted to take fewer pills along with a meal.  

Warning - A Possible Danger - Xofigo in Combination with Zytiga and Prednisone

The European Medicines Agency (EMA) has recommended halting the use of the Xofigo (radium-223 dichloride) in combination with Zytiga (abiraterone acetate) and prednisone due to a possible increased risk of death and fractures.

The FDA Approves Abiraterone Acetate for Some Men with Castrate Sensitive Metastatic Prostate Cancer

The Food and Drug Administration approved the use of abiraterone acetate (Zytiga) with prednisone for men with high-risk, castration-sensitive, chemotherapy-naive metastatic prostate cancer, but there are some hitches and hurdles.