I am not in the habit of publishing entire abstracts, but given the considerable interest in the therapy termed "BAT" or bipolar androgen therapy, I thought that this specific abstract, along with the link to the complete guide, would answer many questions that we hear regularly.

This guide is written in plain language and is specifically designed for patients and their families. It is written by Dr. Samuel Deneade, M.D., the father of BAT.

Abstract

Bipolar androgen therapy (BAT) is a new treatment concept for men whose prostate cancer has become resistant to standard hormone‐blocking therapy. Over the past decade, we have performed a series of clinical studies testing BAT in asymptomatic men with castration‐resistant prostate cancer. The key findings from these clinical studies are that BAT (a) can be safely administered to asymptomatic patients with metastatic castrate‐resistant prostate cancer; (b) does not produce symptomatic disease progression; (c) produces sustained prostate‐specific antigen and objective responses in 30%–40% of patients; and (d) can resensitize and prolong response to subsequent antiandrogen therapy. The concept of BAT has generated significant interest from men with prostate cancer, their families, and their physicians. Here we provide a "Patient's Guide" that answers questions about BAT in a form that is accessible to patients, their families, and physicians. Our goal is to provide information to help patients make the most informed decisions they can regarding their prostate cancer treatment.

The complete guide should be your stepping-off point if you are interested in BAT.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313844/

Prostate. 2022 May 15; 82(7): 753–762.

Published online 2022 Mar 31. doi: 10.1002/pros.24328

PMCID: PMC9313844

PMID: 35357024